Retinopathy of prematurity: risk factors and clinical management in a cohort of ELBW infants

The etiology of retinopathy of prematurity (ROP) is multifactorial while ROP is also frequently associated with other co-morbidity characteristics in former preterm infants. We describe the current risk factors associated with the development of pre-threshold ROP in a cohort of 267 ELBW (extreme low birth weight, i.e. < 1 000 g) infants. We hereby confirm the combined risk associated with immaturity and disease severity. When compared to earlier reported cohorts of the same unit, we document a minor reduction in incidence, with an overall high incidence in neonates at threshold of viability (≤ 26 weeks gestational age). Finally, specific observations on analgosedation and tolerance during screening for ROP or laser surgery are discussed. Key-Words: prematurity – retinopathy of prematurity – visual impairment – risk factors – prevention